Polymorphous lowgrade adenocarcinoma of submandibular gland. Treatment list for polymorphous lowgrade adenocarcinoma. Polymorphous low grade adenocarcinoma of submandibular gland origin yutaka yamazaki a, atsuko hirai a, makoto ishikawa a, shingo moriya b, tadashi iizuka c, yoshimasa kitagawa a a oral diagnosis and medicine, department of oral pathobiological science, graduate school of dental medicine, hokkaido university, kita nishi7, kitaku, sapporo. Although relatively rare, polymorphous adenocarcinoma pac is likely the second most common malignancy of the minor salivary glands misg. As the name implies, polymorphous lowgrade adenocarcinoma plga is a lowgrade neoplasm consisting of a uniform population of tumor cells that are arranged in a variety of architectural patterns polymorphous. If you have problems viewing pdf files, download the latest version of adobe reader.
Jan 15, 20 this study is an analysis of the prevalence of polymorphous low grade adenocarcinoma plga in epidemiological surveys of salivary tumors published in the english language from 1992 to 2012. Oral surg oral med oral pathol oral radiol endod 91 2. Oct 12, 2014 polymorphous low grade adenocarcinoma plga is one such tumor, misunderstood, underdiagnosed, controversial in nomenclature and unpredictable in behavior. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy.
Abstractobjective to study the immunohistochemical pattern of cd 117, glial fibrillary. Polymorphous lowgrade adenocarcinomas are minor salivary gland neoplasms with a predilection for intraoral sites. Plga is predominantly found in females in their sixth to seventh decade, and it most commonly arises in the minor salivary glands, with more than half of cases involving the palate. Polymorphous lowgrade adenocarcinoma apamed central. Polymorphous lowgrade adenocarcinoma synonyms, polymorphous. We report the first case of a polymorphous low grade adenocarcinoma plga occurring in the vulva and vagina of a 32yearold woman. Recent studies on polymorphous low grade adenocarcinoma pdf. The 57 surveys for which it was possible to calculate the percentage of plgas among all malignant minor salivary gland. Polymorphous low grade adenocarcinoma of the upper lip. Pdf polymorphous low grade adenocarcinoma james castle. Polymorphous lowgrade adenocarcinoma is a rare malignancy arising from the minor salivary glands in the aerodigestive system, most frequently the hard palate. Unlike the poor prognosis seen in many triple negative breast tumors, salivary glandlike tumors, including polymorphous adenocarcinoma, may have a more favorable prognosis. Polymorphous low grade adenocarcinoma has only rarely been reported in britain, but we believe it deserves wider recognition as a distinct clinicopathological entity and, in particular, separation. Antonyms for polymorphous low grade adenocarcinoma.
The concept of dedifferentiation had previously been used in salivary gland carcinomas. In contrast, polymorphous lowgrade adenocarcinoma plga has a. Before its original recognition as an independent entity in 1983, most cases of plga were included in the spectrum of adenoid cystic carcinoma adcc, and. I describing the occurrence of hepatic fibrinring granulomas in a patient with systemic lupus erythematosus. Polymorphous low grade adenocarcinoma with distant metastases. It has a varied microscopic architectural appearance, i.
Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Polymorphous lowgrade adenocarcinoma libre pathology. It is important to differentiate plga from other salivary gland tumors with myoepithelial differentiation such as pleomorphic adenoma and adenoid cystic carcinoma. Polymorphous adenocarcinoma of the salivary glands. We describe our experience with 17 patients treated at our institution for plga from 1984 to 2012. Previously, pac was referred to as polymorphous low grade. Polymorphous low grade adenocarcinoma of the hard palate. Triad of infiltrative growth, multiple architectural growth patterns, cellular uniformity nonencapsulated but often well circumscribed tumor with diverse polymorphous growth patterns cribriform, fascicular, microcystic, mixed, papillary focal, pseudoadenoid cystic without true lumens, single file, solid, strandlike, tubular am j surg pathol 1984.
What are the signs and symptoms of polymorphous lowgrade adenocarcinoma of salivary gland. Women are affected twice as frequently as men, and generally present in the fifth to sixth decade of life with a painless ihaoral mass. Treatments for polymorphous lowgrade adenocarcinoma. Polymorphous low grade adenocarcinoma of the salivary glands with transformation to high grade carcinoma. Polymorphous lowgrade adenocarcinoma of the salivary glands with transformation to highgrade carcinoma.
The palate or roof of the mouth, is the most common site for plga. Patients are usually middleaged to elderly, more often women. The major salivary glands are the parotid glands at the side of the face. Polymorphous low grade adenocarcinoma plga is a rare malignancy most commonly seen in the minor salivary glands. Always seek professional medical advice about any treatment or change in treatment plans. Polymorphous lowgrade adenocarcinoma of the tongue base. Polymorphous lowgrade adenocarcinoma of salivary gland signs and symptoms may include the following. First described in 1983, this entity has been recognized to have an indolent course with rare metastases or deaths. Polymorphous low grade adenocarcinoma plga is a slowgrowing salivary gland malignancy with a nonaggressive behaviour. Plga accounts for 7 11% of all benign and malignant neoplasms and about 19 26% of all malignancies in minor salivary glands.
This tumor consisted of cellular lobules with distinct cribriform, papillary, and cystic patterns. Ckit expression distinguishes salivary gland adenoid. This study analyzes the demographic, clinicopathologic, incidence, and survival characteristics of head and neck plga hn. Immunohistochemical pattern of pleomorphic adenoma. Polymorphous low grade adenocarcinoma with distant. This parotid epithelialmyoepithelial carcinoma shows a solid growth pattern with scattered tubules and mostly shows elongated nuclei with open chromatin and delicate nuclear membranes reminiscent of polymorphous low grade adenocarcinoma original magnification. Mar 16, 2020 as the name implies, polymorphous low grade adenocarcinoma plga is a low grade neoplasm consisting of a uniform population of tumor cells that are arranged in a variety of architectural patterns polymorphous.
Polymorphous low grade adenocarcinoma is a rare, malignant salivary gland tumor, which is found almost exclusively in minor salivary glands. Like many of the salivary glandlike tumors of the breast, polymorphous adenocarcinoma is a triple negative, basallike tumor appl immunohistochem mol morphol 20. Salivary glands primary salivary gland neoplasms malignant polymorphous adenocarcinoma. What are synonyms for polymorphous lowgrade adenocarcinoma. Polymorphous lowgrade adenocarcinoma of the vulva and vagina. Polymorphous low grade adenocarcinoma plga is a rare tumor that mostly affects minor salivary glands. The tumor mass may grow at a slow rate in the mouth and may present no pain. Polymorphous lowgrade adenocarcinoma of maxillary alveolus. Low grade polymorphous adenocarcinoma is a malignant neoplasm of salivary glands with uncommon occurrence in the head and neck region, almost exclusively affecting minor salivary glands.
It is most commonly found in the palate the name of the tumor derives from the fact that. We report a case of a 55 year old male who presented with an asymptomatic swelling on the hard palate. Polymorphous lowgrade adenocarcinoma has only rarely been reported in britain, but we believe it deserves wider recognition as a distinct clinicopathological entity and, in particular, separation. Polymorphous lowgrade adenocarcinoma of salivary gland. To date, this entity has been identified either within the confines of the oral cavity or, rarely, in the nasal cavity. Polymorphous lowgrade adenocarcinoma plga is a rare tumor that mostly affects minor salivary glands. Metastases to locoregional lymph nodes occur in only 610% of cases. Dec 17, 2018 what are the signs and symptoms of polymorphous low grade adenocarcinoma of salivary gland. Synonyms for polymorphous low grade adenocarcinoma in free thesaurus. Pdf polymorphous low grade adenocarcinomas plga are minor salivary gland neoplasms with a predilection for. Polymorphous lowgrade adenocarcinoma of the lacrimal. Pdf polymorphous lowgrade adenocarcinoma plga, is a rare, salivary gland intraoral tumor with complexities in. Polymorphous lowgrade adenocarcinoma of seromucous glands of.
Introduction polymorphous lowgrade adenocarcinoma plga is a rare malignant tumor which mostly develops in minor salivary glands. We were interested to read the recent report by murphy et a1. Polymorphous lowgrade adenocarcinoma of the vulva and. It has previously been known as terminal duct carcinoma, lobular carcinoma, and low grade papillary adenocarcinoma. In such cases, it is critical to make a definite diagnosis as each of these tumors has an entirely different treatment protocol. We report the first case of a polymorphous lowgrade adenocarcinoma plga occurring in the vulva and vagina of a 32yearold woman. In contrast, polymorphous low grade adenocarcinoma plga has a much lower. Polymorphous low grade adenocarcinoma plga originating mostly in the minor salivary glands of the posterior hard and soft palate is characterised by its indolent growth and a slower rate of metastasis.
Polymorphous lowgrade adenocarcinoma of the salivary gland, plga. Previously, pac was referred to as polymorphous lowgrade. It occurs primarily in the minor salivary glands but. Seldom does the plga present an aggressive behaviour and demonstrate distant metastasis, as in the present case where a 73yearold female patient with a swelling in the maxillary alveolus was. Polymorphous lowgrade adenocarcinoma is a lowgrade and indolent neoplasm, with 1020% risk of local recurrence, and low risk for distant metastasis and death due to plga.
Polymorphous lowgrade adenocarcinoma genetic and rare. Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland. The diagnosis is mainly based on an incisional biopsy. Synonyms for polymorphous lowgrade adenocarcinoma in free thesaurus. This is a lowgrade malignancy characterised by bland cytology and various architectural patterns. Polymorphous lowgrade adenocarcinoma of the upper lip. Recently, the term highgrade transformation was introduced for adenoid cystic carcinoma, acinic cell carcinoma, epithelialmyoepithelial carcinoma, and polymorphous lowgrade adenocarcinoma and may better reflect this phenomenon, although transformation into moderately differentiated adenocarcinoma. A 67yearold man was initially seen with painless right upper eyelidswelling and conjunctival hyperemia across a 2day period. Polymorphous low grade adenocarcinoma of salivary gland signs and symptoms may include the following. Polymorphous lowgrade adenocarcinoma plga has been known as a comparatively less aggressive malignant tumor that predominantly occurs in the minor. It is more frequent in the thirdseventh decade of life, with a clear female predilection in a 2. For language access assistance, contact the ncats public information officer. Polymorphous low grade adenocarcinoma versus pleomorphic adenoma of minor salivary glands.
Polymorphous lowgrade adenocarcinoma lester dr thompson. Polymorphous lowgrade adenocarcinoma of submandibular. It has previously been known as terminal duct carcinoma, lobular carcinoma, and lowgrade papillary adenocarcinoma. Symptoms of polymorphous low grade adenocarcinoma including 5 medical symptoms and signs of polymorphous low grade adenocarcinoma, alternative diagnoses, misdiagnosis, and correct diagnosis for polymorphous low grade adenocarcinoma signs or polymorphous low grade adenocarcinoma symptoms. It can also occur in minor salivary glands in the rest of the upper aero. Also called terminal duct carcinoma, lobular carcinoma, low grade papillary adenocarcinoma 10% of minor salivary gland tumors but only 1% of all malignant salivary gland tumors. Polymorphous lowgrade adenocarcinomamanagement and.
This tumor was recognized as a distinct entity in 1983 by freedman and lumerman and batsakis et al. Treatment list for polymorphous low grade adenocarcinoma the list of treatments mentioned in various sources for polymorphous low grade adenocarcinoma includes the following list. The treatment of choice is wide surgical resection, and the efficacy of radiotherapy has not been confirmed. Sep 21, 2014 polymorphous low grade adenocarcinoma plga is the second most frequent type of malignant tumor of the minor salivary glands. Polymorphous low grade adenocarcinoma, salivary gland tumors.
Polymorphous lowgrade adenocarcinoma plga is the second most frequent type of malignant tumor of the minor salivary glands. Polymorphous lowgrade adenocarcinoma plga is a rare tumor of the salivary glands that is limited, to a great extent, to the minor salivary glands and commonly, but not exclusively, localized in the palate of the mouth. The term polymorphous lowgrade adenocarcinoma plga was introduced by evans and batsakis in 1984 to describe a cytologically bland. The list of treatments mentioned in various sources for polymorphous lowgrade adenocarcinoma includes the following list. To date, this entity has been identified either within the confines.
Polymorphous low grade adenocarcinoma plga is an indolent malignant tumor affecting the minor salivary gland almost exclusively. Polymorphous lowgrade adenocarcinoma plga is a malignant epithelial tumor characterized by cytological uniformity. Polymorphous lowgrade adenocarcinoma is a low grade and indolent neoplasm, with 1020% risk of local recurrence, and low risk for distant metastasis and death due to plga. Polymorphous low grade adenocarcinomas are minor salivary gland neoplasms with a predilection for intraoral sites. Hotspot activating prkd1 somatic mutations in polymorphous. Polymorphous lowgrade adenocarcinoma of the palate. Seldom does the plga present an aggressive behaviour and demonstrate distant metastasis, as in the present case where a 73yearold female patient with a swelling in the maxillary. This paper describes the radiographic extent of the lesion and the findings of ct imaging. Polymorphous lowgrade adenocarcinoma of the parotid. Polymorphous low grade adenocarcinomas plgas are thought to be indolent tumours that are localised preferentially to the palate and affect the minor salivary glands almost exclusively. Examination revealed him to be afebrile with a visual acuity of 612 od and69 os, 6 mm of proptosis, 3mm inferior globe displacement, temporal. Polymorphous lowgrade adenocarcinoma nord national.
Polymorphous lowgrade adenocarcinoma plga is a minor salivary gland neoplasm that is characterized by morphologic variability, cytologic uniformity, and an infiltrating growth pattern. The term polymorphous lowgrade adenocarcinoma was later adopted in the 2nd who classification of 1991 and defined as a malignant epithelial tumour characterized by cytological uniformity, morphological diversity and a low metastatic potential. Symptoms of polymorphous lowgrade adenocarcinoma including 5 medical symptoms and signs of polymorphous lowgrade adenocarcinoma, alternative diagnoses, misdiagnosis, and correct diagnosis for polymorphous lowgrade adenocarcinoma signs or polymorphous low. Among salivary gland malignancies, polymorphous lowgrade adenocarcinoma plga clearly illustrates such diagnostic dif. Ckit expression distinguishes salivary gland adenoid cystic. A case report in a male 48 he had history of foul smelling discharge from the mouth, dysphagia, odynophagia, bleeding, weight loss. Polymorphous lowgrade adenocarcinoma plga is a slowgrowing salivary gland malignancy with a nonaggressive behaviour. This article is from journal of dentistry tehran, iran, volume 11. Polymorphous low grade adenocarcinoma of the parotid in a. Adenoid cystic carcinoma acc is characterized by persistent, relentless growth and a high rate of eventual metastasis. These surveys included studies from different researchers, countries and continents. The purpose of this study is to report six new cases followedup during a long period.
Case report polymorphous lowgrade adenocarcinoma of submandibular gland origin yutaka yamazaki a, atsuko hirai a, makoto ishikawa a, shingo moriya b, tadashi iizuka c, yoshimasa kitagawa a a oral diagnosis and medicine, department of oral pathobiological science, graduate school of dental medicine, hokkaido university, kita nishi7, kitaku, sapporo 0608586, japan. Polymorphous low grade adenocarcinoma plga is a minor salivary gland neoplasm that is characterized by morphologic variability, cytologic uniformity, and an infiltrating growth pattern. Polymorphous lowgrade adenocarcinoma plga is a rare, asymptomatic, slowgrowing malignant salivary gland tumor. This case lent further support to the suggestion that these lesions are a relatively nonspecific hepatic. The term polymorphous lowgrade adenocarcinoma plga was introduced by evans and batsakis 1 in 1984 to describe a cytologically bland but architecturally diverse malignant neoplasm of minor salivary gland origin that had been previously recognized as lobular carcinoma, 2 terminal duct carcinoma, 3 and lowgrade papillary adenocarcinoma. A carcinoma commonly misclassified as polymorphous low grade adenocarcinoma hematoxylineosin staining used in both parts of figure. Polymorphous lowgrade adenocarcinoma of the parotid gland.
Polymorphous lowgrade adenocarcinoma plga originating mostly in the minor salivary glands of the posterior hard and soft palate is characterised by its indolent growth and a slower rate of metastasis. Polymorphous lowgrade adenocarcinoma plga is one such tumor, misunderstood, underdiagnosed, controversial in nomenclature and unpredictable in behavior. Polymorphous low grade adenocarcinoma plga is a rare tumor of the salivary glands that is limited, to a great extent, to the minor salivary glands and commonly, but not exclusively, localized in the palate of the mouth. Polymorphous lowgrade adenocarcinoma of seromucous. Polymorphous low grade adenocarcinoma plga occurs mostly in minor salivary glands, and there are only a few reports of major salivary gland origin. Polymorphous lowgrade adenocarcinoma definition of. Polymorphous lowgrade adenocarcinoma of the lacrimal gland. Polymorphous lowgrade adenocarcinoma plga is a malignant epithelial tumor characterized by cytological uniformity, morphological diversity, an infiltrative growth pattern and low metastatic potential. Examination revealed him to be afebrile with a visual acuity of 612 od and69 os, 6 mm of proptosis, 3mm inferior globe displacement, temporal conjunctivalhyperemia, and a. Polymorphous low grade adenocarcinoma plga is a rare, asymptomatic, slowgrowing malignant salivary gland tumor. These tumors tend to start in the minor salivary glands. Polymorphous lowgrade adenocarcinoma plga is a rare tumor of the salivary. A 54yearold male presenting with a mass at the base of the tongue performed transoral laser microsurgery. Polymorphous low grade adenocarcinoma plga is a rare salivary gland neoplasm with an indolent course.
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